latest update: June 23, 2015, at 09:41 AM
See you all next year at BioPPN 2015 in Brussels.
CEUR Workshop Proceedings Vol-1159
session chair: Monika Heiner
session chair: Annegret Wagler
session chair: Jetty Kleijn
Universitŕ degli Studi di Torino, Dipartimento di Informatica
Mathematical models on cancer progression
The Cancer Stem Cell (CSC) involvement into tumor progression, tumor recurrence, and therapy resistance is one of the most studied subject of current cancer research. Nevertheless, due to the complex dynamics characterizing the CSC tumor, a comprehensive theory has not been established yet. To this end, some advises can be obtained combining mathematical modeling and experimental data. Indeed, mathematical modeling is a powerful instrument which may drive the comprehension of a biological system, providing a clear description of its essential dynamics.
The aim of this talk is hence to show how the CSC tumor growth could be described/studied through the application of mathematical models. In details two different modeling approaches are presented: the former one consists in a multilevel/multiscale model, which details both molecular and cellular aspects. By means of this framework we were able to reproduce the tumor growth trend observed in mice, highlighting the strong connection existing between cellular events and cell population dynamics. We were also able to reproduce molecular vaccinations, correctly miming the in vivo vaccinations in animals. However, this detailed approach can engender difficulties in the parameter estimation process when only few kinetic information is available.
The second contribution was designed really to address this complexity issue. We defined a new compartmental mathematical framework only focusing on the cell subpopulation dynamics. Indeed, the aim of this work was to describe CSC tumor progression trying to identify its essential mechanisms at population level. Through a quantitative and qualitative analysis of our model was hence possible to define rules controlling the breast cancer progression.
Lastly, we point out that the CSC theory is applicable to several other human cancers. Therefore, being our two model based on the key dynamics of the CSC theory, they can be further adapted for the study of many other tumor cases too.
The goal of this workshop is to provide a platform for researchers aiming at fundamental research and real life applications of Petri nets in Systems and Synthetic Biology.
Systems and Synthetic Biology are full of challenges and open issues, with adequate modelling and analysis techniques being one of them.
Petri nets offer a family of related models, which can be used as a kind of umbrella formalism — models may share the network structure, but vary in their kinetic details (quantitative information). This clearly contributes to bridging the gap between different formalisms, and helps to unify diversity.
Case studies in systems and synthetic biology demonstrating the specific power by the combined use of different Petri net classes are especially encouraged.
This workshop intends to gather students and researchers, who have interests in the application of Petri nets for biological processes. Its main goal will be to demonstrate that Petri net can be an effective technique to tackle the issues which reside in many biological problems. The workshop also promotes discussions between advanced researchers and beginners, which may enhance the world-wide activities in Petri net applications on biological processes.
Submitted papers should describe original work that has not been previously published and is not under review for publication elsewhere. All papers should be in LNCS format, and have to be submitted via EasyChair. The page limit given below includes figures, tables and references.
There are the following categories of submissions.
A submission should be clearly assigned to one category.
Based on the review process, a submission may be accepted as is, accepted with minor changes, rejected or selected for oral presentation only. In the latter case, an abstract can be published.
Proceedings will be electronically published with CEUR Workshop Proceedings (http://ceur-ws.org) with consecutive volume numbers for each workshop allocated with PETRI NETS 2014, as well as local proceedings distributed via USB Memory Sticks.
Best papers will be proposed to be invited for the follow-up publication in Transactions on Petri Nets and other models of Concurrency (ToPNoC).
Institut Pasteur de Tunis, Tunisia
alia.benkahl (at) pasteur.rns.tn
Brandenburg University of Technology, Computer Science Institute, Germany
monika.heiner (at) b-tu.de
Registration is handled by the hosting conference website PETRI NETS 2014