\beginnet{akap_N} \const{\type{double}\name{CONC}\value{12}} \const{\type{integer}\name{N}} \const{\type{double}\name{H}\value{CONC/N}} \const{\type{integer}\name{camp_max}\value{10*N}} \const{\type{integer}\name{camp_init}\value{0}} \const{\type{integer}\name{basal_camp}\value{0}} \const{\type{integer}\name{scaffold_init}\value{N}} \const{\type{integer}\name{u_scaffold_init}\value{N}} \const{\type{integer}\name{scaffold_max}\value{N}} \const{\type{integer}\name{u_scaffold_max}\value{N}} \const{\type{integer}\name{pde8_init}\value{N/2}} \const{\type{integer}\name{pde8_max}\value{N/2}} \const{\type{integer}\name{pde8_p_init}\value{0}} \const{\type{integer}\name{pde8_p_max}\value{N/2}} \const{\type{integer}\name{pp_init}\value{scaffold_init}} \const{\type{integer}\name{pp_u_init}\value{u_scaffold_init}} \const{\type{integer}\name{T}} \const{\type{double}\name{diffuse_rate_cAMP}\value{1}} \const{\type{double}\name{diffuse_rate_PP}\value{1}} \const{\type{double}\name{pka_activate1}\value{1}} \const{\type{double}\name{camp_inhib}\value{1}} \const{\type{double}\name{camp_more_inhib}\value{2.5}} \const{\type{double}\name{raf_phospho}\value{1}} \const{\type{double}\name{raf_dephospho}\value{1}} \const{\type{double}\name{release_camp1}\value{1}} \const{\type{double}\name{release_camp2}\value{1.5*release_camp1}} \const{\type{double}\name{release_camp3}\value{2.0*release_camp2}} \const{\type{double}\name{pde8_phospho}\value{raf_phospho}} \const{\type{double}\name{pde8_dephospho}\value{raf_dephospho}} \const{\type{double}\name{p_pde8_degrade}\value{raf_dephospho}} \const{\type{double}\name{pde8_degrade}\value{raf_dephospho/3}} \const{\type{double}\name{free_pde8_phospho}\value{pde8_phospho/3}} \const{\type{double}\name{free_pde8_dephospho}\value{free_pde8_phospho}} \const{\type{double}\name{free_p_pde8_degrade}\value{p_pde8_degrade/3}} \const{\type{double}\name{free_pde8_degrade}\value{pde8_degrade/3}} \const{\type{integer}\name{p}\value{2}} \const{\type{integer}\name{tick_max}\value{10}} \const{\type{integer}\name{tick_med}\value{5}} \place{P_0}{\name{cAMP}\capacity{1}\init{0}} \place{P_1}{\name{tick}\capacity{1}\init{0}} \place{P_2}{\name{S00}\capacity{1}\init{N}} \place{P_3}{\name{S10}\capacity{1}\init{0}} \place{P_4}{\name{S01}\capacity{1}\init{0}} \place{P_5}{\name{S11}\capacity{1}\init{0}} \place{P_6}{\name{S000}\capacity{1}\init{N}} \place{P_7}{\name{S100}\capacity{1}\init{0}} \place{P_8}{\name{S101}\capacity{1}\init{0}} \place{P_9}{\name{S110}\capacity{1}\init{0}} \place{P_10}{\name{S011}\capacity{1}\init{0}} \place{P_11}{\name{S010}\capacity{1}\init{0}} \place{P_12}{\name{S001}\capacity{1}\init{0}} \place{P_13}{\name{S111}\capacity{1}\init{0}} \place{P_14}{\name{PP_u}\capacity{1}\init{N}} \place{P_15}{\name{PP}\capacity{1}\init{N}} \place{P_16}{\name{PDE8_P}\capacity{1}\init{0}} \place{P_17}{\name{PDE8}\capacity{1}\init{pde8_init}} \transition{T_0}{\name{free_PDE8_degrades_cAMP} \function{cAMP*H*PDE8*free_pde8_degrade}} \transition{T_1}{\name{free_pPDE8_degrades_cAMP} \function{cAMP*H*PDE8_P*free_p_pde8_degrade}} \transition{T_2}{\name{diffuse3_in_cAMP} \function{diffuse_rate_cAMP/H}} \transition{T_3}{\name{diffuse2_in_cAMP} \function{diffuse_rate_cAMP/H}} \transition{T_4}{\name{diffuse1_in_cAMP} \function{diffuse_rate_cAMP/H}} \transition{T_5}{\name{PDE8_degrades_cAMP_3} \function{S000*H*cAMP*pde8_degrade}} \transition{T_6}{\name{PDE8_degrades_cAMP_1} \function{S100*H*cAMP*pde8_degrade}} \transition{T_7}{\name{release1cAMP} \function{S111*1*release_camp1}} \transition{T_8}{\name{release1cAMP_u} \function{S11*1*release_camp1}} \transition{T_9}{\name{pPDE8_degrades_cAMP1} \function{S011*H*cAMP*p_pde8_degrade}} \transition{T_10}{\name{pPDE8_degrades_cAMP2} \function{S001*H*cAMP*p_pde8_degrade}} \transition{T_11}{\name{PDE8_degrades_cAMP_2} \function{S110*H*cAMP*pde8_degrade}} \transition{T_12}{\name{PDE8_degrades_cAMP_4} \function{S010*H*cAMP*pde8_degrade}} \transition{T_13}{\name{activate_u_PKA_1} \function{S00*H*cAMP*pka_activate1}} \transition{T_14}{\name{activate_PKA_1} \function{S000*H*cAMP*pka_activate1}} \transition{T_15}{\name{dephospho1_Raf} \function{S010*H*PP*raf_dephospho}} \transition{T_16}{\name{dephospho_u_Raf} \function{S01*H*PP*raf_dephospho}} \transition{T_17}{\name{dephospho2_Raf} \function{S011*H*PP*raf_dephospho}} \transition{T_18}{\name{PP_dephospho_pPDE8_1} \function{S011*PP*pde8_dephospho}} \transition{T_19}{\name{phospho_Raf} \function{S100*raf_phospho}} \transition{T_20}{\name{phospho_Raf_pPDE8} \function{S101*raf_phospho}} \transition{T_21}{\name{phospho_PDE8} \function{S100*pde8_phospho}} \transition{T_22}{\name{phospho_PDE8_pRaf} \function{S110*pde8_phospho}} \transition{T_23}{\name{phospho_u_Raf} \function{S10*raf_phospho}} \transition{T_24}{\name{PP_dephospho_pPDE8_2} \function{PP*S001*pde8_dephospho}} \transition{T_25}{\name{dephospho_free_PDE8} \function{PDE8_P*H*PP_u*free_pde8_dephospho}} \transition{T_26}{\name{phospho_u_PDE8_bis} \function{PDE8*H*S11*free_pde8_phospho}} \transition{T_27}{\name{phospho_u_PDE8} \function{PDE8*H*S10*free_pde8_phospho}} \arc{A_0}{\from{P_0} \to{T_0} \weight{1} \type{ordinary}} \arc{A_1}{\from{P_17} \to{T_0} \weight{1} \type{ordinary}} \arc{A_2}{\from{T_0} \to{P_17} \weight{1} \type{ordinary}} \arc{A_3}{\from{P_0} \to{T_1} \weight{1} \type{ordinary}} \arc{A_4}{\from{P_16} \to{T_1} \weight{1} \type{ordinary}} \arc{A_5}{\from{T_1} \to{P_16} \weight{1} \type{ordinary}} \arc{A_6}{\from{P_1} \to{T_2} \weight{10} \type{ordinary}} \arc{A_7}{\from{P_0} \to{T_2} \weight{camp_max} \type{inhibitor}} \arc{A_8}{\from{T_2} \to{P_0} \weight{1} \type{ordinary}} \arc{A_9}{\from{P_1} \to{T_3} \weight{5} \type{ordinary}} \arc{A_10}{\from{P_0} \to{T_3} \weight{camp_max - 1} \type{inhibitor}} \arc{A_11}{\from{P_1} \to{T_3} \weight{tick_max} \type{inhibitor}} \arc{A_12}{\from{T_3} \to{P_1} \weight{6} \type{ordinary}} \arc{A_13}{\from{P_0} \to{T_4} \weight{camp_max} \type{inhibitor}} \arc{A_14}{\from{P_1} \to{T_4} \weight{tick_med} \type{inhibitor}} \arc{A_15}{\from{T_4} \to{P_1} \weight{1} \type{ordinary}} \arc{A_16}{\from{T_4} \to{P_0} \weight{1} \type{ordinary}} \arc{A_17}{\from{P_0} \to{T_5} \weight{1} \type{ordinary}} \arc{A_18}{\from{P_6} \to{T_5} \weight{1} \type{ordinary}} \arc{A_19}{\from{T_5} \to{P_6} \weight{1} \type{ordinary}} \arc{A_20}{\from{P_0} \to{T_6} \weight{1} \type{ordinary}} \arc{A_21}{\from{P_7} \to{T_6} \weight{1} \type{ordinary}} \arc{A_22}{\from{T_6} \to{P_7} \weight{1} \type{ordinary}} \arc{A_23}{\from{P_13} \to{T_7} \weight{1} \type{ordinary}} \arc{A_24}{\from{P_0} \to{T_7} \weight{camp_max} \type{inhibitor}} \arc{A_25}{\from{P_10} \to{T_7} \weight{N} \type{inhibitor}} \arc{A_26}{\from{T_7} \to{P_0} \weight{1} \type{ordinary}} \arc{A_27}{\from{T_7} \to{P_10} \weight{1} \type{ordinary}} \arc{A_28}{\from{P_5} \to{T_8} \weight{1} \type{ordinary}} \arc{A_29}{\from{P_0} \to{T_8} \weight{camp_max} \type{inhibitor}} \arc{A_30}{\from{P_4} \to{T_8} \weight{N} \type{inhibitor}} \arc{A_31}{\from{T_8} \to{P_0} \weight{1} \type{ordinary}} \arc{A_32}{\from{T_8} \to{P_4} \weight{1} \type{ordinary}} \arc{A_33}{\from{P_0} \to{T_9} \weight{1} \type{ordinary}} \arc{A_34}{\from{P_10} \to{T_9} \weight{1} \type{ordinary}} \arc{A_35}{\from{T_9} \to{P_10} \weight{1} \type{ordinary}} \arc{A_36}{\from{P_0} \to{T_10} \weight{1} \type{ordinary}} \arc{A_37}{\from{P_12} \to{T_10} \weight{1} \type{ordinary}} \arc{A_38}{\from{T_10} \to{P_12} \weight{1} \type{ordinary}} \arc{A_39}{\from{P_0} \to{T_11} \weight{1} \type{ordinary}} \arc{A_40}{\from{P_9} \to{T_11} \weight{1} \type{ordinary}} \arc{A_41}{\from{T_11} \to{P_9} \weight{1} \type{ordinary}} \arc{A_42}{\from{P_0} \to{T_12} \weight{1} \type{ordinary}} \arc{A_43}{\from{P_11} \to{T_12} \weight{1} \type{ordinary}} \arc{A_44}{\from{T_12} \to{P_11} \weight{1} \type{ordinary}} \arc{A_45}{\from{P_0} \to{T_13} \weight{1} \type{ordinary}} \arc{A_46}{\from{P_2} \to{T_13} \weight{1} \type{ordinary}} \arc{A_47}{\from{P_3} \to{T_13} \weight{N} \type{inhibitor}} \arc{A_48}{\from{T_13} \to{P_3} \weight{1} \type{ordinary}} \arc{A_49}{\from{P_0} \to{T_14} \weight{1} \type{ordinary}} \arc{A_50}{\from{P_6} \to{T_14} \weight{1} \type{ordinary}} \arc{A_51}{\from{P_7} \to{T_14} \weight{N} \type{inhibitor}} \arc{A_52}{\from{T_14} \to{P_7} \weight{1} \type{ordinary}} \arc{A_53}{\from{P_11} \to{T_15} \weight{1} \type{ordinary}} \arc{A_54}{\from{P_15} \to{T_15} \weight{1} \type{ordinary}} \arc{A_55}{\from{P_6} \to{T_15} \weight{N} \type{inhibitor}} \arc{A_56}{\from{T_15} \to{P_6} \weight{1} \type{ordinary}} \arc{A_57}{\from{T_15} \to{P_15} \weight{1} \type{ordinary}} \arc{A_58}{\from{P_4} \to{T_16} \weight{1} \type{ordinary}} \arc{A_59}{\from{P_15} \to{T_16} \weight{1} \type{ordinary}} \arc{A_60}{\from{P_2} \to{T_16} \weight{N} \type{inhibitor}} \arc{A_61}{\from{T_16} \to{P_2} \weight{1} \type{ordinary}} \arc{A_62}{\from{T_16} \to{P_15} \weight{1} \type{ordinary}} \arc{A_63}{\from{P_10} \to{T_17} \weight{1} \type{ordinary}} \arc{A_64}{\from{P_15} \to{T_17} \weight{1} \type{ordinary}} \arc{A_65}{\from{P_12} \to{T_17} \weight{N} \type{inhibitor}} \arc{A_66}{\from{T_17} \to{P_12} \weight{1} \type{ordinary}} \arc{A_67}{\from{T_17} \to{P_15} \weight{1} \type{ordinary}} \arc{A_68}{\from{P_10} \to{T_18} \weight{1} \type{ordinary}} \arc{A_69}{\from{P_15} \to{T_18} \weight{1} \type{ordinary}} \arc{A_70}{\from{P_11} \to{T_18} \weight{N} \type{inhibitor}} \arc{A_71}{\from{T_18} \to{P_11} \weight{1} \type{ordinary}} \arc{A_72}{\from{T_18} \to{P_15} \weight{1} \type{ordinary}} \arc{A_73}{\from{P_7} \to{T_19} \weight{1} \type{ordinary}} \arc{A_74}{\from{P_9} \to{T_19} \weight{N} \type{inhibitor}} \arc{A_75}{\from{T_19} \to{P_9} \weight{1} \type{ordinary}} \arc{A_76}{\from{P_8} \to{T_20} \weight{1} \type{ordinary}} \arc{A_77}{\from{P_13} \to{T_20} \weight{N} \type{inhibitor}} \arc{A_78}{\from{T_20} \to{P_13} \weight{1} \type{ordinary}} \arc{A_79}{\from{P_7} \to{T_21} \weight{1} \type{ordinary}} \arc{A_80}{\from{P_8} \to{T_21} \weight{N} \type{inhibitor}} \arc{A_81}{\from{T_21} \to{P_8} \weight{1} \type{ordinary}} \arc{A_82}{\from{P_9} \to{T_22} \weight{1} \type{ordinary}} \arc{A_83}{\from{P_13} \to{T_22} \weight{N} \type{inhibitor}} \arc{A_84}{\from{T_22} \to{P_13} \weight{1} \type{ordinary}} \arc{A_85}{\from{P_3} \to{T_23} \weight{1} \type{ordinary}} \arc{A_86}{\from{P_5} \to{T_23} \weight{N} \type{inhibitor}} \arc{A_87}{\from{T_23} \to{P_5} \weight{1} \type{ordinary}} \arc{A_88}{\from{P_12} \to{T_24} \weight{1} \type{ordinary}} \arc{A_89}{\from{P_15} \to{T_24} \weight{1} \type{ordinary}} \arc{A_90}{\from{P_6} \to{T_24} \weight{N} \type{inhibitor}} \arc{A_91}{\from{T_24} \to{P_6} \weight{1} \type{ordinary}} \arc{A_92}{\from{T_24} \to{P_15} \weight{1} \type{ordinary}} \arc{A_93}{\from{P_14} \to{T_25} \weight{1} \type{ordinary}} \arc{A_94}{\from{P_16} \to{T_25} \weight{1} \type{ordinary}} \arc{A_95}{\from{P_17} \to{T_25} \weight{pde8_max} \type{inhibitor}} \arc{A_96}{\from{T_25} \to{P_14} \weight{1} \type{ordinary}} \arc{A_97}{\from{T_25} \to{P_17} \weight{1} \type{ordinary}} \arc{A_98}{\from{P_5} \to{T_26} \weight{1} \type{ordinary}} \arc{A_99}{\from{P_17} \to{T_26} \weight{1} \type{ordinary}} \arc{A_100}{\from{P_16} \to{T_26} \weight{pde8_p_max} \type{inhibitor}} \arc{A_101}{\from{T_26} \to{P_5} \weight{1} \type{ordinary}} \arc{A_102}{\from{T_26} \to{P_16} \weight{1} \type{ordinary}} \arc{A_103}{\from{P_3} \to{T_27} \weight{1} \type{ordinary}} \arc{A_104}{\from{P_17} \to{T_27} \weight{1} \type{ordinary}} \arc{A_105}{\from{P_16} \to{T_27} \weight{pde8_p_max} \type{inhibitor}} \arc{A_106}{\from{T_27} \to{P_3} \weight{1} \type{ordinary}} \arc{A_107}{\from{T_27} \to{P_16} \weight{1} \type{ordinary}} \endnet