MoPS - Modelling Pain Switches

      BMBF Funding Number: 0315449H

Project description



In the BTU team, Petri nets are applied to modeling and analysis of pain switches, which allow the application of powerful analysis techniques ranging from graph theory, linear algebra via model checking to simulation methods. The Petri net formalism is extremely powerful for modelling the nociception network because it can represent different mechanisms and data types, like the activity of extracellular mediators, signal transducers, intracellular second messengers including their spatial distribution in the cell or tissue, effectors such as ion channels, and membrane potential changes to even subjectively graded parameters like pain in a time-resolved manner.


Prof. Dr. Christoph Stein
Prof. Dr. med. Ralf Baron
Prof. Dr. Med. Peter Reeh
Prof. Wolfgang Marwan
MicroDiscovery GmbH
Prof. Dr.-Ing. Monika Heiner
Dr. Tim Hucho (main coordinator)
Prof. Dr. Friedrich Herberg
Dr. Harald Seitz

Related papers

  • Report for Berlin meeting [November 2010]
  • Report for Kassel meeting [May 2010]
  • Report for Magdeburg meeting [January 2010]
  • Report for Cottbus meeting [August 2009]
  • Report for Kiel meeting [June 2009]
  • Poster Heidelberg MoPS A0 [June 2009]
  • Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology [August 2007]
  • Results

    PN Application in MoPS: pain switch, two first basic models [Hucho 2008]


    MoPS web site from MicroDiscovery

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